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    Modeling mechanical interactions in growing populations of rod-shaped bacteria

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    Author
    Winkle, James J.; Igoshin, Oleg A.; Bennett, Matthew R.; Josić, Krešimir; Ott, William
    Date
    2017
    Abstract
    Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular fluid flow lead to complex, changing arrangements of cells within the population. To rationally engineer and control the behavior of cell collectives we need theoretical and computational tools to understand their emergent spatiotemporal dynamics. Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions. Crucially, our model couples the dynamics of cell growth to the cell's environment: Mechanical constraints can affect cellular growth rate and a cell may alter its behavior in response to these constraints. This coupling links the mechanical forces that influence cell growth and emergent behaviors in cell assemblies. We illustrate our approach by showing how mechanical interactions can impact the dynamics of bacterial collectives growing in microfluidic traps.
    Citation
    Winkle, James J., Igoshin, Oleg A., Bennett, Matthew R., et al.. "Modeling mechanical interactions in growing populations of rod-shaped bacteria." Physical Biology, 14, no. 5 (2017) IOP Publishing: https://doi.org/10.1088/1478-3975/aa7bae.
    Published Version
    https://doi.org/10.1088/1478-3975/aa7bae
    Type
    Journal article
    Publisher
    IOP Publishing
    Citable link to this page
    https://hdl.handle.net/1911/98823
    Rights
    This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the IOP Press.
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    • Bioengineering Publications [631]
    • BioSciences Publications [364]
    • Faculty Publications [4978]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map