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dc.contributor.authorZhou, Ying
Loeza-Cabrera, Mario
Liu, Zheng
Aleman-Meza, Boanerges
Nguyen, Julie K.
Jung, Sang-Kyu
Choi, Yuna
Shou, Qingyao
Butcher, Rebecca A.
Zhong, Weiwei
dc.date.accessioned 2017-11-14T18:08:24Z
dc.date.available 2017-11-14T18:08:24Z
dc.date.issued 2017
dc.identifier.citation Zhou, Ying, Loeza-Cabrera, Mario, Liu, Zheng, et al.. "Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans." Genetics, 206, no. 3 (2017) Genetics Society of America: 1469-1478. https://doi.org/10.1534/genetics.116.197293.
dc.identifier.urihttps://hdl.handle.net/1911/98809
dc.description.abstract It is crucial for animal survival to detect dangers such as predators. A good indicator of dangers is injury of conspecifics. Here we show that fluids released from injured conspecifics invoke acute avoidance in both free-living and parasitic nematodes. Caenorhabditis elegans avoids extracts from closely related nematode species but not fruit fly larvae. The worm extracts have no impact on animal lifespan, suggesting that the worm extract may function as an alarm instead of inflicting physical harm. Avoidance of the worm extract requires the function of a cGMP signaling pathway that includes the cGMP-gated channel TAX-2/TAX-4 in the amphid sensory neurons ASI and ASK. Genetic evidence indicates that the avoidance behavior is modulated by the neurotransmitters GABA and serotonin, two common targets of anxiolytic drugs. Together, these data support a model that nematodes use a nematode-specific alarm pheromone to detect conspecific injury.
dc.language.iso eng
dc.publisher Genetics Society of America
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Genetics Society of America.
dc.title Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans
dc.type Journal article
dc.citation.journalTitle Genetics
dc.subject.keywordCaenorhabditis elegans
chemotaxis
olfactory
pheromone
dc.citation.volumeNumber 206
dc.citation.issueNumber 3
dc.identifier.digital genetics.116.197293.full
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1534/genetics.116.197293
dc.identifier.pmcid PMC5500144
dc.identifier.pmid 28495959
dc.type.publication post-print
dc.citation.firstpage 1469
dc.citation.lastpage 1478


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