Show simple item record

dc.contributor.authorKim, Jihan
Feng, Jingchen
Jones, Christopher A.R.
Mao, Xiaoming
Sander, Leonard M.
Levine, Herbert
Sun, Bo
dc.date.accessioned 2017-11-06T21:15:05Z
dc.date.available 2017-11-06T21:15:05Z
dc.date.issued 2017
dc.identifier.citation Kim, Jihan, Feng, Jingchen, Jones, Christopher A.R., et al.. "Stress-induced plasticity of dynamic collagen networks." Nature Communications, 8, (2017) Springer Nature: https://doi.org/10.1038/s41467-017-01011-7.
dc.identifier.urihttps://hdl.handle.net/1911/97834
dc.description.abstract The structure and mechanics of tissues is constantly perturbed by endogenous forces originated from cells, and at the same time regulate many important cellular functions such as migration, differentiation, and growth. Here we show that 3D collagen gels, major components of connective tissues and extracellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as well as by macroscopic strains. To understand this ECM plasticity, we develop a computational model that takes into account the sliding and merging of ECM fibers. We have confirmed the model predictions with experiment. Our results suggest the profound impacts of cellular traction forces on their host ECM during development and cancer progression, and suggest indirect mechanical channels of cell-cell communications in 3D fibrous matrices.
dc.language.iso eng
dc.publisher Springer Nature
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Stress-induced plasticity of dynamic collagen networks
dc.type Journal article
dc.citation.journalTitle Nature Communications
dc.citation.volumeNumber 8
dc.identifier.digital Stress-induced_plasticity
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1038/s41467-017-01011-7
dc.identifier.pmcid PMC5635002
dc.identifier.pmid 29018207
dc.type.publication publisher version
dc.citation.articleNumber 842


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record