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    Physical-chemical mechanisms of pattern formation during gastrulation

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    Author
    Bozorgui, Behnaz
    Kolomeisky, Anatoly B.
    Teimouri, Hamid
    Date
    2018
    Citation
    Bozorgui, Behnaz, Kolomeisky, Anatoly B. and Teimouri, Hamid. "Physical-chemical mechanisms of pattern formation during gastrulation." The Journal of Chemical Physics, 148, no. 12 (2018) https://doi.org/10.1063/1.4993879.
    Published Version
    https://doi.org/10.1063/1.4993879
    Abstract
    Gastrulation is a fundamental phase during the biological development of most animals when a single layer of identical embryo cells is transformed into a three-layer structure, from which the organs start to develop. Despite a remarkable progress in quantifying the gastrulation processes, molecular mechanisms of these processes remain not well understood. Here we theoretically investigate early spatial patterning in a geometrically confined colony of embryonic stem cells. Using a reaction-diffusion model, a role of Bone-Morphogenetic Protein 4 (BMP4) signaling pathway in gastrulation is specifically analyzed. Our results show that for slow diffusion rates of BMP4 molecules, a new length scale appears, which is independent of the size of the system. This length scale separates the central region of the colony with uniform low concentrations of BMP molecules from the region near the colony edge where the concentration of signaling molecules is elevated. The roles of different components of the signaling pathway are also explained. Theoretical results are consistent with recent in vitro experiments, providing microscopic explanations for some features of early embryonic spatial patterning. Physical-chemical mechanisms of these processes are discussed.
    Type
    Journal article
    Citable link to this page
    http://hdl.handle.net/1911/97818
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    • Chemistry Publications [456]
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    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892