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dc.contributor.authorLi, Xi
Deem, Michael W.
dc.date.accessioned 2017-08-21T14:34:16Z
dc.date.available 2017-08-21T14:34:16Z
dc.date.issued 2016
dc.identifier.citation Li, Xi and Deem, Michael W.. "Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season." Protein Engineering, Design and Selection, 29, no. 8 (2016) Oxford University Press: 309-315. https://doi.org/10.1093/protein/gzw017.
dc.identifier.urihttps://hdl.handle.net/1911/97375
dc.description.abstract Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the pepitope method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via pepitope. In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.
dc.language.iso eng
dc.publisher Oxford University Press
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season
dc.type Journal article
dc.citation.journalTitle Protein Engineering, Design and Selection
dc.subject.keyworddominant strains
influenza evolution
pepitope
phylogeny
vaccine effectiveness
dc.citation.volumeNumber 29
dc.citation.issueNumber 8
dc.identifier.digital Influenza_evolution_H3N2_vaccine_effectiveness
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1093/protein/gzw017
dc.identifier.pmcid PMC4955871
dc.identifier.pmid 27313229
dc.type.publication publisher version
dc.citation.firstpage 309
dc.citation.lastpage 315


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.