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dc.contributor.authorJolly, Mohit Kumar
Tripathi, Satyendra C.
Somarelli, Jason A.
Hanash, Samir M.
Levine, Herbert
dc.date.accessioned 2017-08-21T14:34:15Z
dc.date.available 2017-08-21T14:34:15Z
dc.date.issued 2017
dc.identifier.citation Jolly, Mohit Kumar, Tripathi, Satyendra C., Somarelli, Jason A., et al.. "Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?." Molecular Oncology, 11, no. 7 (2017) Wiley: 739-754. https://doi.org/10.1002/1878-0261.12084.
dc.identifier.urihttps://hdl.handle.net/1911/97371
dc.description.abstract Phenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize phenotypic plasticity to evade therapies, metastasize, and colonize distant organs. As a result, phenotypic plasticity can accelerate tumor progression. A well-studied example of phenotypic plasticity is the bidirectional conversions among epithelial, mesenchymal, and hybrid epithelial/mesenchymal (E/M) phenotype(s). These conversions can alter a repertoire of cellular traits associated with multiple hallmarks of cancer, such as metabolism, immune evasion, invasion, and metastasis. To tackle the complexity and heterogeneity of these transitions, mathematical models have been developed that seek to capture the experimentally verified molecular mechanisms and act as ‘hypothesis-generating machines’. Here, we discuss how these quantitative mathematical models have helped us explain existing experimental data, guided further experiments, and provided an improved conceptual framework for understanding how multiple intracellular and extracellular signals can drive E/M plasticity at both the single-cell and population levels. We also discuss the implications of this plasticity in driving multiple aggressive facets of tumor progression.
dc.language.iso eng
dc.publisher Wiley
dc.rights This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
dc.type Journal article
dc.citation.journalTitle Molecular Oncology
dc.contributor.org Center for Theoretical Biological Physics
dc.subject.keywordcirculating tumor cells
collective cell migration
epithelial-mesenchymal transition
hybrid epithelial/mesenchymal
mathematical modeling
stemness
dc.citation.volumeNumber 11
dc.citation.issueNumber 7
dc.identifier.digital Epithelial_mesenchymal_plasticity
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1002/1878-0261.12084
dc.identifier.pmcid PMC5496493
dc.identifier.pmid 28548388
dc.type.publication publisher version
dc.citation.firstpage 739
dc.citation.lastpage 754


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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.