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dc.contributor.authorQiu, Yongzhi
Tong, Sheng
Zhang, Linlin
Sakurai, Yumiko
Myers, David R.
Hong, Lin
Lam, Wilbur A.
Bao, Gang
dc.date.accessioned 2017-08-17T19:19:42Z
dc.date.available 2017-08-17T19:19:42Z
dc.date.issued 2017
dc.identifier.citation Qiu, Yongzhi, Tong, Sheng, Zhang, Linlin, et al.. "Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions." Nature Communications, 8, (2017) Springer Nature: https://doi.org/10.1038/ncomms15594.
dc.identifier.urihttps://hdl.handle.net/1911/97339
dc.description.abstract The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.
dc.language.iso eng
dc.publisher Springer Nature
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions
dc.type Journal article
dc.citation.journalTitle Nature Communications
dc.citation.volumeNumber 8
dc.identifier.digital Magnetic_forces
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1038/ncomms15594
dc.identifier.pmcid PMC5472756
dc.type.publication publisher version
dc.citation.articleNumber 15594


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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/