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dc.contributor.authorYu, Guangyuan
Feng, Jingchen
Man, Haoran
Levine, Herbert
dc.date.accessioned 2017-08-09T17:13:27Z
dc.date.available 2017-08-09T17:13:27Z
dc.date.issued 2017
dc.identifier.citation Yu, Guangyuan, Feng, Jingchen, Man, Haoran, et al.. "Phenomenological modeling of durotaxis." Physical Review E, 96, no. 1 (2017) American Physical Society: https://doi.org/10.1103/PhysRevE.96.010402.
dc.identifier.urihttps://hdl.handle.net/1911/96637
dc.description.abstract Cells exhibit qualitatively different behaviors on substrates with different rigidities. The fact that cells are more polarized on the stiffer substrate motivates us to construct a two-dimensional cell with the distribution of focal adhesions dependent on substrate rigidities. This distribution affects the forces exerted by the cell and thereby determines its motion. Our model reproduces the experimental observation that the persistence time is higher on the stiffer substrate. This stiffness-dependent persistence will lead to durotaxis, the preference in moving towards stiffer substrates. This propensity is characterized by the durotaxis index first defined in experiments. We derive and validate a two-dimensional corresponding Fokker-Planck equation associated with our model. Our approach highlights the possible role of the focal adhesion arrangement in durotaxis.
dc.language.iso eng
dc.publisher American Physical Society
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Phenomenological modeling of durotaxis
dc.type Journal article
dc.citation.journalTitle Physical Review E
dc.citation.volumeNumber 96
dc.citation.issueNumber 1
dc.identifier.digital Phenomenological_modeling_durotaxis
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.96.010402
dc.type.publication publisher version
dc.citation.articleNumber 010402(R)


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