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dc.contributor.authorFANTOM Consortium
RIKEN PMI
CLST (DGT)
dc.date.accessioned 2017-08-04T12:30:01Z
dc.date.available 2017-08-04T12:30:01Z
dc.date.issued 2014
dc.identifier.citation FANTOM Consortium, RIKEN PMI and CLST (DGT). "A promoter-level mammalian expression atlas." Nature, 507, (2014) Nature Publishing Group: 462-470. https://doi.org/10.1038/nature13182.
dc.identifier.urihttps://hdl.handle.net/1911/96593
dc.description.abstract Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved. Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs. The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses. The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research.
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Nature Publishing Group.
dc.title A promoter-level mammalian expression atlas
dc.type Journal article
dc.citation.journalTitle Nature
dc.citation.volumeNumber 507
dc.identifier.digital promoter-level_mammalian_expression_atlas
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1038/nature13182
dc.identifier.pmcid PMC4529748
dc.identifier.pmid 24670764
dc.type.publication post-print
dc.citation.firstpage 462
dc.citation.lastpage 470


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