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dc.contributor.authorVila, P.M.
Kingsley, M.J.
Polydorides, A.D.
Protano, M.-A.
Pierce, M.C.
Sauk, J.
Kim, M.K.
Patel, K.
Godbold, J.H.
Waye, J.D.
Richards-Kortum, R.
Anandasabapathy, S.
dc.date.accessioned 2017-08-04T12:29:40Z
dc.date.available 2017-08-04T12:29:40Z
dc.date.issued 2014
dc.identifier.citation Vila, P.M., Kingsley, M.J., Polydorides, A.D., et al.. "Accuracy and interrater reliability for the diagnosis of Barrett’s neoplasia among users of a novel, portable high-resolution microendoscope." Disease of the Esophagus, 27, no. 1 (2014) Oxford University Press: 55-62. https://doi.org/10.1111/dote.12040.
dc.identifier.urihttps://hdl.handle.net/1911/96571
dc.description.abstract The high-resolution microendoscope (HRME) is a novel imaging modality that may be useful in the surveillance of Barrett’s esophagus in low-resource or community-based settings. In order to assess accuracy and interrater reliability of microendoscopists in identifying Barrett’s-associated neoplasia using HRME images, we recruited 20 gastroenterologists with no microendoscopic experience and three expert microendoscopists in a large academic hospital in New York City to interpret HRME images. They prospectively reviewed 40 HRME images from 28 consecutive patients undergoing surveillance for metaplasia and low-grade dysplasia and/or evaluation for high-grade dysplasia or cancer. Images were reviewed in a blinded fashion, after a 4-minute training with 11 representative images. All imaged sites were biopsied and interpreted by an expert pathologist. Sensitivity of all endoscopists for identification of high-grade dysplasia or cancer was 0.90 (95% confidence interval [CI]: 0.88-0.92) and specificity was 0.82 (95% CI: 0.79-0.85). Positive and negative predictive values were 0.72 (95% CI: 0.68-0.77) and 0.94 (95% CI: 0.92-0.96), respectively. No significant differences in accuracy were observed between experts and novices (0.90 vs. 0.84). The kappa statistic for all raters was 0.56 (95% CI: 0.54-0.58), and the difference between groups was not significant (0.64 vs. 0.55). These data suggest that gastroenterologists can diagnose Barrett’s-related neoplasia on HRME images with high sensitivity and specificity, without the aid of prior microendoscopy experience.
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.
dc.title Accuracy and interrater reliability for the diagnosis of Barrett’s neoplasia among users of a novel, portable high-resolution microendoscope
dc.type Journal article
dc.citation.journalTitle Disease of the Esophagus
dc.subject.keywordcancer
diagnostic imaging
esophagogastroduodenoscopy
optical device
dc.citation.volumeNumber 27
dc.citation.issueNumber 1
dc.identifier.digital Accuracy_interrater_reliability
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1111/dote.12040
dc.identifier.pmcid PMC3795799
dc.identifier.pmid 23442220
dc.type.publication post-print
dc.citation.firstpage 55
dc.citation.lastpage 62


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