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    Measuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysis

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    Author
    Benoit, Denise N.
    Zhu, Huiguang
    Lilierose, Michael H.
    Verm, Raymond A.
    Ali, Naushaba
    Morrison, Adam N.
    Fortner, John D.
    Avendano, Carolina
    Colvin, Vicki L.
    Date
    2012
    Citation
    Benoit, Denise N., Zhu, Huiguang, Lilierose, Michael H., et al.. "Measuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysis." Analytical Chemistry, (2012) 9238-9245. https://doi.org/10.1021/ac301980a.
    Published Version
    https://doi.org/10.1021/ac301980a
    Abstract
    Many of the solution phase properties of nanoparticles, such as their colloidal stability and hydrodynamic diameter, are governed by the number of stabilizing groups bound to the particle surface (i.e., grafting density). Here, we show how two techniques, analytical ultracentrifugation (AUC) and total organic carbon analysis (TOC), can be applied separately to the measurement of this parameter. AUC directly measures the density of nanoparticle–polymer conjugates while TOC provides the total carbon content of its aqueous dispersions. When these techniques are applied to model gold nanoparticles capped with thiolated poly(ethylene glycol), the measured grafting densities across a range of polymer chain lengths, polymer concentrations, and nanoparticle diameters agree to within 20%. Moreover, the measured grafting densities correlate well with the polymer content determined by thermogravimetric analysis of solid conjugate samples. Using these tools, we examine the particle core diameter, polymer chain length, and polymer solution concentration dependence of nanoparticle grafting densities in a gold nanoparticle–poly(ethylene glycol) conjugate system.
    Type
    Journal article
    Citable link to this page
    http://hdl.handle.net/1911/96164
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    • Chemistry Publications [403]
    • Faculty Publications [2827]

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    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892