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dc.contributor.authorBurger, Anat
Walczak, Aleksandra M.
Wolynes, Peter G.
dc.date.accessioned 2017-08-02T14:52:15Z
dc.date.available 2017-08-02T14:52:15Z
dc.date.issued 2012
dc.identifier.citation Burger, Anat, Walczak, Aleksandra M. and Wolynes, Peter G.. "Influence of decoys on the noise and dynamics of gene expression." Physical Review E, 86, no. 4 (2012) American Physical Society: https://doi.org/10.1103/PhysRevE.86.041920.
dc.identifier.urihttps://hdl.handle.net/1911/96163
dc.description.abstract Many transcription factors bind to DNA with a remarkable lack of specificity, so that regulatory binding sites compete with an enormous number of nonregulatory “decoy” sites. For an autoregulated gene, we show decoy sites decrease noise in the number of unbound proteins to a Poisson limit that results from binding and unbinding. This noise buffering is optimized for a given protein concentration when decoys have a 1/2 probability of being occupied. Decoys linearly increase the time to approach steady state and exponentially increase the time to switch epigenetically between bistable states.
dc.language.iso eng
dc.publisher American Physical Society
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Influence of decoys on the noise and dynamics of gene expression
dc.type Journal article
dc.citation.journalTitle Physical Review E
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 86
dc.citation.issueNumber 4
dc.identifier.digital Influence_decoys_noise_dynamics_gene_expression
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.86.041920
dc.identifier.pmid 23214628
dc.type.publication publisher version
dc.citation.articleNumber 041920


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