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    Influence of decoys on the noise and dynamics of gene expression

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    Author
    Burger, Anat; Walczak, Aleksandra M.; Wolynes, Peter G.
    Date
    2012
    Abstract
    Many transcription factors bind to DNA with a remarkable lack of specificity, so that regulatory binding sites compete with an enormous number of nonregulatory “decoy” sites. For an autoregulated gene, we show decoy sites decrease noise in the number of unbound proteins to a Poisson limit that results from binding and unbinding. This noise buffering is optimized for a given protein concentration when decoys have a 1/2 probability of being occupied. Decoys linearly increase the time to approach steady state and exponentially increase the time to switch epigenetically between bistable states.
    Citation
    Burger, Anat, Walczak, Aleksandra M. and Wolynes, Peter G.. "Influence of decoys on the noise and dynamics of gene expression." Physical Review E, 86, no. 4 (2012) American Physical Society: https://doi.org/10.1103/PhysRevE.86.041920.
    Published Version
    https://doi.org/10.1103/PhysRevE.86.041920
    Type
    Journal article
    Publisher
    American Physical Society
    Citable link to this page
    https://hdl.handle.net/1911/96163
    Rights
    Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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    • Chemistry Publications [705]
    • Faculty Publications [5504]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map