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dc.contributor.authorHernández-Rivera, Mayra
Kumar, Ish
Cho, Stephen Y.
Cheong, Benjamin Y.
Pulikkathara, Merlyn X.
Moghaddam, Sakineh E.
Whitmire, Kenton H.
Wilson, Lon J.
dc.date.accessioned 2017-08-01T16:54:56Z
dc.date.available 2017-08-01T16:54:56Z
dc.date.issued 2017
dc.identifier.citation Hernández-Rivera, Mayra, Kumar, Ish, Cho, Stephen Y., et al.. "High-Performance Hybrid Bismuth–Carbon Nanotube Based Contrast Agent for X-ray CT Imaging." ACS Applied Materials & Interfaces, 9, no. 7 (2017) American Chemical Society: 5709-5716. https://doi.org/10.1021/acsami.6b12768.
dc.identifier.urihttps://hdl.handle.net/1911/96033
dc.description.abstract Carbon nanotubes (CNTs) have been used for a plethora of biomedical applications, including their use as delivery vehicles for drugs, imaging agents, proteins, DNA, and other materials. Here, we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultrashort single-walled carbon nanotubes (20–80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today due to its high X-ray attenuation capability and its low toxicity, which makes bismuth a more-promising element for new CT CA design. The new CA contains 20% by weight bismuth with no detectable release of bismuth after a 48 h challenge by various biological media at 37 °C, demonstrating the presence of a strong interaction between the two components of the hybrid material. The performance of the new Bi4C@US-tubes solid material as a CT CA has been assessed using a clinical scanner and found to possess an X-ray attenuation ability of >2000 Hounsfield units (HU).
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title High-Performance Hybrid Bismuth–Carbon Nanotube Based Contrast Agent for X-ray CT Imaging
dc.type Journal article
dc.citation.journalTitle ACS Applied Materials & Interfaces
dc.subject.keywordcarbon nanotubes
bismuth
X-ray CT
radiocontrast agent
dc.citation.volumeNumber 9
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1021/acsami.6b12768
dc.identifier.pmid 28072512
dc.type.publication post-print
dc.citation.firstpage 5709
dc.citation.lastpage 5716


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