Development of New Methods for the Synthesis of Novel Biaryls
Keene, Craig Allen
Doctor of Philosophy
Herein the first organocatalytic atroposelective synthesis of BINAM derivatives is detailed. The findings of which inspired the development of new methodology directed toward the synthesis of 3-substituted-2-nitronaphthalene building blocks. The nitronaphthalenes were then utilized in a new approach aimed at the synthesis of symmetrical and unsymmetrical diaryl hydrazines. A novel approach for the synthesis of functionalized, non-C2-symmetric, atropisomeric biaryls in a one-pot transformation is also described.