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dc.contributor.authorSchultz, Daniel
Lu, Mingyang
Stavropoulos, Trevor
Onuchic, José
Ben-Jacob, Eshel
dc.date.accessioned 2017-07-31T18:12:33Z
dc.date.available 2017-07-31T18:12:33Z
dc.date.issued 2013
dc.identifier.citation Schultz, Daniel, Lu, Mingyang, Stavropoulos, Trevor, et al.. "Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate." Scientific Reports, 3, (2013) Nature Publishing Group: http://dx.doi.org/10.1038/srep01668.
dc.identifier.urihttps://hdl.handle.net/1911/95631
dc.description.abstract Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate
dc.type Journal article
dc.citation.journalTitle Scientific Reports
dc.citation.volumeNumber 3
dc.identifier.digital Turning_Oscillations_Into_Opportunities
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1038/srep01668
dc.identifier.pmcid PMC3627974
dc.type.publication publisher version
dc.citation.articleNumber 1668


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