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dc.contributor.authorRaoof, Mustafa
Corr, Stuart J.
Zhu, Cihui
Cisneros, Brandon T.
Kaluarachchi, Warna D.
Phounsavath, Sophia
Wilson, Lon J.
Curley, Steven A.
dc.date.accessioned 2017-06-15T15:30:09Z
dc.date.available 2017-06-15T15:30:09Z
dc.date.issued 2014
dc.identifier.citation Raoof, Mustafa, Corr, Stuart J., Zhu, Cihui, et al.. "Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma." Nanomedicine: Nanotechnology, Biology and Medicine, 10, no. 6 (2014) Elsevier: 1121-1130. https://doi.org/10.1016/j.nano.2014.03.004.
dc.identifier.urihttps://hdl.handle.net/1911/94861
dc.description.abstract Hepatocellular carcinoma (HCC) is one of the most lethal and chemo-refractory cancers, clearly, alternative treatment strategies are needed. We utilized 10 nm gold nanoparticles as a scaffold to synthesize nanoconjugates bearing a targeting antibody (cetuximab, C225) and gemcitabine. Loading efficiency of gemcitabine on the gold nanoconjugates was 30%. Targeted gold nanoconjugates in combination with RF were selectively cytotoxic to EGFR expressing Hep3B and SNU449 cells when compared to isotype particles with/without RF (P < 0.05). In animal experiments, targeted gold nanoconjugates halted the growth of subcutaneous Hep3B xenografts in combination with RF exposure (P < 0.05). These xenografts also demonstrated increased apoptosis, necrosis and decreased proliferation compared to controls. Normal tissues were unharmed. We have demonstrated that non-invasive RF-induced hyperthermia when combined with targeted delivery of gemcitabine is more effective and safe at dosages ~ 275-fold lower than the current clinically-delivered systemic dose of gemcitabine.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma
dc.type Journal article
dc.citation.journalTitle Nanomedicine: Nanotechnology, Biology and Medicine
dc.contributor.org Richard E. Smalley Institute for Nanoscale Science & Technology
dc.subject.keywordGemcitabine
Hepatocellular
Hyperthermia
Nanoparticle
Radiofrequency
dc.citation.volumeNumber 10
dc.citation.issueNumber 6
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1016/j.nano.2014.03.004
dc.identifier.pmcid PMC4349335
dc.identifier.pmid 24650884
dc.type.publication post-print
dc.citation.firstpage 1121
dc.citation.lastpage 1130


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