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dc.contributor.authorKumar, Vivek A.
Taylor, Nichole L.
Shi, Siyu
Wang, Benjamin K.
Jalan, Abhishek A.
Kang, Marci K.
Wickremasinghe, Navindee C.
Hartgerink, Jeffrey D.
dc.date.accessioned 2017-06-14T18:46:24Z
dc.date.available 2017-06-14T18:46:24Z
dc.date.issued 2015
dc.identifier.citation Kumar, Vivek A., Taylor, Nichole L., Shi, Siyu, et al.. "Highly Angiogenic Peptide Nanofibers." ACS Nano, 9, no. 1 (2015) American Chemical Society: 860-868. https://doi.org/10.1021/nn506544b.
dc.identifier.urihttps://hdl.handle.net/1911/94846
dc.description.abstract Major limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation byproducts. Specifically, for scaffolds larger than 200–500 μm, implants must be accompanied by host angiogenesis in order to provide adequate nutrient/waste exchange in the newly forming tissue. In the current work, we design a peptide-based self-assembling nanofibrous hydrogel containing cell-mediated degradation and proangiogenic moieties that specifically address these challenges. This hydrogel can be easily delivered by syringe, is rapidly infiltrated by cells of hematopoietic and mesenchymal origin, and rapidly forms an extremely robust mature vascular network. Scaffolds show no signs of fibrous encapsulation and after 3 weeks are resorbed into the native tissue. These supramolecular assemblies may prove a vital paradigm for tissue regeneration and specifically for ischemic tissue disease.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Highly Angiogenic Peptide Nanofibers
dc.type Journal article
dc.citation.journalTitle ACS Nano
dc.subject.keywordangiogenesis
multidomain peptide
self-assembly
supramolecular chemistry
dc.citation.volumeNumber 9
dc.citation.issueNumber 1
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1021/nn506544b
dc.identifier.pmcid PMC4370274
dc.identifier.pmid 25584521
dc.type.publication post-print
dc.citation.firstpage 860
dc.citation.lastpage 868


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