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dc.contributor.authorQuinto, Christopher A.
Mohindra, Priya
Tong, Sheng
Bao, Gang
dc.date.accessioned 2017-06-14T18:46:24Z
dc.date.available 2017-06-14T18:46:24Z
dc.date.issued 2015
dc.identifier.citation Quinto, Christopher A., Mohindra, Priya, Tong, Sheng, et al.. "Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment." Nanoscale, 7, (2015) Royal Society of Chemistry: 12728-12736. https://doi.org/10.1039/C5NR02718G.
dc.identifier.urihttps://hdl.handle.net/1911/94845
dc.description.abstract Superparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and hyperthermia. To explore this potential, we synthesized SPIOs with a phospholipid-polyethylene glycol (PEG) coating, and loaded Doxorubicin (DOX) with a 30.8% w/w loading capacity when the PEG length is optimized. We found that DOX-loaded SPIOs exhibited a sustained DOX release over 72 hours where the release kinetics could be altered by the PEG length. In contrast, the heating efficiency of the SPIOs showed minimal change with the PEG length. With a core size of 14 nm, the SPIOs could generate sufficient heat to raise the local temperature to 43 °C, sufficient to trigger apoptosis in cancer cells. Further, we found that DOX-loaded SPIOs resulted in cell death comparable to free DOX, and that the combined effect of DOX and SPIO-induced hyperthermia enhanced cancer cell death in vitro. This study demonstrates the potential of using phospholipid-PEG coated SPIOs for chemotherapy–hyperthermia combinatorial cancer treatment with increased efficacy.
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.title Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment
dc.type Journal article
dc.citation.journalTitle Nanoscale
dc.citation.volumeNumber 7
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1039/C5NR02718G
dc.identifier.pmcid PMC4507566
dc.identifier.pmid 26154916
dc.type.publication post-print
dc.citation.firstpage 12728
dc.citation.lastpage 12736


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