Show simple item record

dc.contributor.authorKinard, Lucas A.
Dahlin, Rebecca L.
Lam, Johnny
Lu, Steven
Lee, Esther J.
Kasper, F. Kurtis
Mikos, Antonios G.
dc.date.accessioned 2017-06-14T16:55:02Z
dc.date.available 2017-06-14T16:55:02Z
dc.date.issued 2014
dc.identifier.citation Kinard, Lucas A., Dahlin, Rebecca L., Lam, Johnny, et al.. "Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model." Acta Biomaterialia, 10, no. 11 (2014) Elsevier: 4574-4582. https://doi.org/10.1016/j.actbio.2014.07.011.
dc.identifier.urihttps://hdl.handle.net/1911/94836
dc.description.abstract There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has the potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1 or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Selected formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated in vivo compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation, exceeding 1:1 constructs and empty implants by 3- and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlates directly to the DBM dose.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
dc.type Journal article
dc.citation.journalTitle Acta Biomaterialia
dc.subject.keywordBone augmentation
Demineralized bone matrix
Oligo(poly(ethylene glycol) fumarate)
Synthetic hydrogel
dc.citation.volumeNumber 10
dc.citation.issueNumber 11
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2014.07.011
dc.identifier.pmcid PMC4186894
dc.identifier.pmid 25046637
dc.type.publication post-print
dc.citation.firstpage 4574
dc.citation.lastpage 4582


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record