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    Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model

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    Author
    Kinard, Lucas A.; Dahlin, Rebecca L.; Lam, Johnny; Lu, Steven; Lee, Esther J.; More... Kasper, F. Kurtis; Mikos, Antonios G. Less...
    Date
    2014
    Abstract
    There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has the potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1 or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Selected formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated in vivo compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation, exceeding 1:1 constructs and empty implants by 3- and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlates directly to the DBM dose.
    Citation
    Kinard, Lucas A., Dahlin, Rebecca L., Lam, Johnny, et al.. "Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model." Acta Biomaterialia, 10, no. 11 (2014) Elsevier: 4574-4582. https://doi.org/10.1016/j.actbio.2014.07.011.
    Published Version
    https://doi.org/10.1016/j.actbio.2014.07.011
    Keyword
    Bone augmentation; Demineralized bone matrix; Oligo(poly(ethylene glycol) fumarate); Synthetic hydrogel
    Type
    Journal article
    Publisher
    Elsevier
    Citable link to this page
    https://hdl.handle.net/1911/94836
    Rights
    This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
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    • Bioengineering Publications [632]
    • Chemical and Biomolecular Engineering Publications [253]
    • Faculty Publications [4988]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map