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dc.contributor.authorShin, Dongsuk
Protano, Marion-Anna
Polydorides, Alexandros D.
Dawsey, Sanford M.
Pierce, Mark C.
Kim, Michelle Kang
Schwarz, Richard A.
Quang, Timothy
Parikh, Neil
Bhutani, Manoop S.
Zhang, Fan
Wang, Guiqi
Xue, Liyan
Wang, Xueshan
Xu, Hong
Anandasabapathy, Sharmila
Richards-Kortum, Rebecca R.
dc.date.accessioned 2017-06-05T21:25:24Z
dc.date.available 2017-06-05T21:25:24Z
dc.date.issued 2015
dc.identifier.citation Shin, Dongsuk, Protano, Marion-Anna, Polydorides, Alexandros D., et al.. "Quantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaᅠ." Clinical Gastroenterology and Hepatology, 13, no. 2 (2015) Elsevier: 272-279.e2. https://doi.org/10.1016/j.cgh.2014.07.030.
dc.identifier.urihttps://hdl.handle.net/1911/94810
dc.description.abstract Background & Aims: High-resolution microendoscopy is an optical imaging technique with the potential to improve the accuracy of endoscopic screening for esophageal squamous neoplasia. Although these microscopic images can be interpreted readily by trained personnel, quantitative image analysis software could facilitate the use of this technology in low-resource settings. In this study, we developed and evaluated quantitative image analysis criteria for the evaluation of neoplastic and non-neoplastic squamous esophageal mucosa. Methods: We performed an image analysis of 177 patients undergoing standard upper endoscopy for screening or surveillance of esophageal squamous neoplasia, using high-resolution microendoscopy, at 2 hospitals in China and at 1 hospital in the United States from May 2010 to October 2012. Biopsy specimens were collected from imaged sites (n = 375), and a consensus diagnosis was provided by 2 expert gastrointestinal pathologists and used as the standard. Results: Quantitative information from the high-resolution images was used to develop an algorithm to identify high-grade squamous dysplasia or invasive squamous cell cancer, based on histopathology findings. Optimal performance was obtained using the mean nuclear area as the basis for classification, resulting in sensitivities and specificities of 93% and 92% in the training set, 87% and 97% in the test set, and 84% and 95% in an independent validation set, respectively. Conclusions: High-resolution microendoscopy with quantitative image analysis can aid in the identification of esophageal squamous neoplasia. Use of software-based image guides may overcome issues of training and expertise in low-resource settings, allowing for widespread use of these optical biopsy technologies.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Quantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaᅠ
dc.type Journal article
dc.citation.journalTitle Clinical Gastroenterology and Hepatology
dc.subject.keywordDiagnostic
Esophageal Cancer
HRME
Quantitative Diagnosis
dc.citation.volumeNumber 13
dc.citation.issueNumber 2
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1016/j.cgh.2014.07.030
dc.identifier.pmcid PMC4305504
dc.identifier.pmid 25066838
dc.type.publication post-print
dc.citation.firstpage 272
dc.citation.lastpage 279.e2


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