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dc.contributor.authorAlmeida, Joao Paulo Mattos
Lin, Adam Yuh
Figueroa, Elizabeth Raquel
Foster, Aaron Edward
Drezek, Rebekah Anna
dc.date.accessioned 2017-05-22T18:57:18Z
dc.date.available 2017-05-22T18:57:18Z
dc.date.issued 2015
dc.identifier.citation Almeida, Joao Paulo Mattos, Lin, Adam Yuh, Figueroa, Elizabeth Raquel, et al.. "In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models." Small, 11, no. 12 (2015) Wiley: 1453-1459. http://dx.doi.org/10.1002/smll.201402179.
dc.identifier.urihttps://hdl.handle.net/1911/94334
dc.description.abstract Gold nanoparticles (AuNPs) are promising vehicles for cancer immunotherapy, with demonstrated efficacy in immune delivery and innate cell stimulation. Nevertheless, their potential has yet to be assessed in the in vivo application of peptide cancer vaccines. In this study, it is hypothesized that the immune distribution and adjuvant qualities of AuNPs could be leveraged to facilitate delivery of the ovalbumin (OVA) peptide antigen and the CpG adjuvant and enhance their therapeutic effect in a B16-OVA tumor model. AuNP delivery of OVA (AuNP-OVA) and of CpG (AuNP-CpG) enhanced the efficacy of both agents and induced strong antigen-specific responses. In addition, it is found that AuNP-OVA delivery alone, without CpG, is sufficient to promote significant antigen-specific responses, leading to subsequent anti-tumor activity and prolonged survival in both prophylactic and therapeutic in vivo tumor models. This enhanced therapeutic efficacy is likely due to the adjuvant effect of peptide coated AuNPs, as they induce inflammatory cytokine release when cultured with bone marrow dendritic cells. Overall, AuNP-mediated OVA peptide delivery can produce significant therapeutic benefits without the need of adjuvant, indicating that AuNPs are effective peptide vaccine carriers with the potential to permit the use of lower and safer adjuvant doses during vaccination.
dc.language.iso eng
dc.publisher Wiley
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.title In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models
dc.type Journal article
dc.citation.journalTitle Small
dc.subject.keywordbiodistribution
cancer
gold nanoparticles
immune system
immunotherapy
dc.citation.volumeNumber 11
dc.citation.issueNumber 12
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1002/smll.201402179
dc.identifier.pmcid PMC4373976
dc.identifier.pmid 25354691
dc.type.publication post-print
dc.citation.firstpage 1453
dc.citation.lastpage 1459


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