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dc.contributor.authorKumar, Vivek A.
Wickremasinghe, Navindee C.
Shi, Siyu
Hartgerink, Jeffrey D.
dc.date.accessioned 2017-05-15T21:11:38Z
dc.date.available 2017-05-15T21:11:38Z
dc.date.issued 2015
dc.identifier.citation Kumar, Vivek A., Wickremasinghe, Navindee C., Shi, Siyu, et al.. "Nanofibrous Snake Venom Hemostat." ACS Biomaterials Science & Engineering, 1, no. 12 (2015) American Chemical Society: 1300-1305. http://dx.doi.org/10.1021/acsbiomaterials.5b00356.
dc.identifier.urihttps://hdl.handle.net/1911/94270
dc.description.abstract Controlling perioperative bleeding is of critical importance to minimize hemorrhaging and fatality. Patients on anticoagulant therapy such as heparin have diminished clotting potential and are at risk for hemorrhaging. Here we describe a self-assembling nanofibrous peptide hydrogel (termed SLac) that on its own can act as a physical barrier to blood loss. SLac was loaded with snake-venom derived Batroxobin (50 μg/mL) yielding a drug-loaded hydrogel (SB50). SB50 was potentiated to enhance clotting even in the presence of heparin. In vitro evaluation of fibrin and whole blood clotting helped identify appropriate concentrations for hemostasis in vivo. Batroxobin-loaded hydrogels rapidly (within 20s) stop bleeding in both normal and heparin-treated rats in a lateral liver incision model. Compared to standard of care, Gelfoam, and investigational hemostats such as Puramatrix, only SB50 showed rapid liver incision hemostasis post surgical application. This snake venom-loaded peptide hydrogel can be applied via syringe and conforms to the wound site resulting in hemostasis. This demonstrates a facile method for surgical hemostasis even in the presence of anticoagulant therapies.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Nanofibrous Snake Venom Hemostat
dc.type Journal article
dc.citation.journalTitle ACS Biomaterials Science & Engineering
dc.subject.keywordhemostasis
multidomain peptide
self-assembly
supramolecular chemistry
dc.citation.volumeNumber 1
dc.citation.issueNumber 12
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/acsbiomaterials.5b00356
dc.identifier.pmcid PMC4704453
dc.identifier.pmid 26753175
dc.type.publication post-print
dc.citation.firstpage 1300
dc.citation.lastpage 1305


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