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dc.contributor.authorWickremasinghe, Navindee C.
Kumar, Vivek A.
Shi, Siyu
Hartgerink, Jeffrey D.
dc.date.accessioned 2017-05-12T15:04:32Z
dc.date.available 2017-05-12T15:04:32Z
dc.date.issued 2015
dc.identifier.citation Wickremasinghe, Navindee C., Kumar, Vivek A., Shi, Siyu, et al.. "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels." ACS Biomaterials Science & Engineering, 1, no. 9 (2015) American Chemical Society: 845-854. http://dx.doi.org/10.1021/acsbiomaterials.5b00210.
dc.identifier.urihttps://hdl.handle.net/1911/94235
dc.description.abstract Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices. Scaffolds showed expected rapid infiltration of macrophages. When released through liposomes incorporated in MDP gels (MDP(Lipo)), PlGF-1 modulates HUVEC VEGF receptor activation in vitro and robust vessel formation in vivo. These loaded MDP(Lipo) hydrogels induce a high level of growth-factor-mediated neovascular maturity. MDP(Lipo) hydrogels offer a biocompatible and injectable platform to tailor drug delivery and treat ischemic tissue diseases.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels
dc.type Journal article
dc.citation.journalTitle ACS Biomaterials Science & Engineering
dc.subject.keywordself-assembly
multidomain peptide
liposomal encapsulation
PlGF-1
cellular infiltration
angiogenesis
dc.citation.volumeNumber 1
dc.citation.issueNumber 9
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/acsbiomaterials.5b00210
dc.identifier.pmcid PMC4768747
dc.identifier.pmid 26925462
dc.type.publication post-print
dc.citation.firstpage 845
dc.citation.lastpage 854


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