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    Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels

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    Author
    Wickremasinghe, Navindee C.; Kumar, Vivek A.; Shi, Siyu; Hartgerink, Jeffrey D.
    Date
    2015
    Abstract
    Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices. Scaffolds showed expected rapid infiltration of macrophages. When released through liposomes incorporated in MDP gels (MDP(Lipo)), PlGF-1 modulates HUVEC VEGF receptor activation in vitro and robust vessel formation in vivo. These loaded MDP(Lipo) hydrogels induce a high level of growth-factor-mediated neovascular maturity. MDP(Lipo) hydrogels offer a biocompatible and injectable platform to tailor drug delivery and treat ischemic tissue diseases.
    Citation
    Wickremasinghe, Navindee C., Kumar, Vivek A., Shi, Siyu, et al.. "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels." ACS Biomaterials Science & Engineering, 1, no. 9 (2015) American Chemical Society: 845-854. http://dx.doi.org/10.1021/acsbiomaterials.5b00210.
    Published Version
    http://dx.doi.org/10.1021/acsbiomaterials.5b00210
    Keyword
    self-assembly; multidomain peptide; liposomal encapsulation; PlGF-1; cellular infiltration; More... angiogenesis Less...
    Type
    Journal article
    Publisher
    American Chemical Society
    Citable link to this page
    https://hdl.handle.net/1911/94235
    Rights
    This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
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    • Bioengineering Publications [632]
    • Chemistry Publications [636]
    • Faculty Publications [4990]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map