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dc.contributor.authorWang, Shenshen
Wolynes, Peter G.
dc.date.accessioned 2017-05-12T15:04:31Z
dc.date.available 2017-05-12T15:04:31Z
dc.date.issued 2013
dc.identifier.citation Wang, Shenshen and Wolynes, Peter G.. "Active patterning and asymmetric transport in a model actomyosin network." The Journal of Chemical Physics, 139, no. 23 (2013) AIP Publishing LLC: http://dx.doi.org/10.1063/1.4848657.
dc.identifier.urihttps://hdl.handle.net/1911/94223
dc.description.abstract Cytoskeletal networks, which are essentially motor-filament assemblies, play a major role in many developmental processes involving structural remodeling and shape changes. These are achieved by nonequilibrium self-organization processes that generate functional patterns and drive intracellular transport. We construct a minimal physical model that incorporates the coupling between nonlinear elastic responses of individual filaments and force-dependent motor action. By performing stochastic simulations we show that the interplay of motor processes, described as driving anti-correlated motion of the network vertices, and the network connectivity, which determines the percolation character of the structure, can indeed capture the dynamical and structural cooperativity which gives rise to diverse patterns observed experimentally. The buckling instability of individual filaments is found to play a key role in localizing collapse events due to local force imbalance. Motor-driven buckling-induced node aggregation provides a dynamic mechanism that stabilizes the two-dimensional patterns below the apparent static percolation limit. Coordinated motor action is also shown to suppress random thermal noise on large time scales, the two-dimensional configuration that the system starts with thus remaining planar during the structural development. By carrying out similar simulations on a three-dimensional anchored network, we find that the myosin-driven isotropic contraction of a well-connected actin network, when combined with mechanical anchoring that confers directionality to the collective motion, may represent a novel mechanism of intracellular transport, as revealed by chromosome translocation in the starfish oocyte.
dc.language.iso eng
dc.publisher AIP Publishing LLC
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Active patterning and asymmetric transport in a model actomyosin network
dc.type Journal article
dc.citation.journalTitle The Journal of Chemical Physics
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 139
dc.citation.issueNumber 23
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1063/1.4848657
dc.type.publication publisher version
dc.citation.articleNumber 235103


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