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dc.contributor.authorShvets, Alexey A.
Kolomeisky, Anatoly B.
dc.date.accessioned 2017-05-09T20:16:06Z
dc.date.available 2017-05-09T20:16:06Z
dc.date.issued 2016
dc.identifier.citation Shvets, Alexey A. and Kolomeisky, Anatoly B.. "Sequence heterogeneity accelerates protein search for targets on DNA." The Journal of Chemical Physics, 143, no. 24 (2016) AIP Publishing LLC: http://dx.doi.org/10.1063/1.4937938.
dc.identifier.urihttps://hdl.handle.net/1911/94209
dc.description.abstract The process of protein search for specific binding sites on DNA is fundamentally important since it marks the beginning of all major biological processes. We present a theoretical investigation that probes the role of DNA sequence symmetry, heterogeneity, and chemical composition in the protein search dynamics. Using a discrete-state stochastic approach with a first-passage events analysis, which takes into account the most relevant physical-chemical processes, a full analytical description of the search dynamics is obtained. It is found that, contrary to existing views, the protein search is generally faster on DNA with more heterogeneous sequences. In addition, the search dynamics might be affected by the chemical composition near the target site. The physical origins of these phenomena are discussed. Our results suggest that biological processes might be effectively regulated by modifying chemical composition, symmetry, and heterogeneity of a genome.
dc.language.iso eng
dc.publisher AIP Publishing LLC
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Sequence heterogeneity accelerates protein search for targets on DNA
dc.type Journal article
dc.citation.journalTitle The Journal of Chemical Physics
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 143
dc.citation.issueNumber 24
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1063/1.4937938
dc.identifier.pmid 26723711
dc.type.publication publisher version
dc.citation.articleNumber 245101


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