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dc.contributor.authorLeonetti, Christopher
Butt, Craig M.
Hoffman, Kate
Miranda, Marie Lynn
Stapleton, Heather M.
dc.date.accessioned 2017-05-03T19:58:19Z
dc.date.available 2017-05-03T19:58:19Z
dc.date.issued 2016
dc.identifier.citation Leonetti, Christopher, Butt, Craig M., Hoffman, Kate, et al.. "Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues." Environment International, 88, (2016) Elsevier: 23-29. https://doi.org/10.1016/j.envint.2015.12.002.
dc.identifier.urihttps://hdl.handle.net/1911/94148
dc.description.abstract Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010 and 2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09 ng/g lipid (range: 0.12–141 ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4 ng/g lipid (range:1.31–316 ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs = − 0.16; p = 0.10 and rs = − 0.17; p = 0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
dc.type Journal article
dc.citation.journalTitle Environment International
dc.subject.keywordBrominated flame retardants
Polybrominated diphenyl ethers
Thyroid hormone
Placenta
dc.citation.volumeNumber 88
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1016/j.envint.2015.12.002
dc.identifier.pmcid PMC4755871
dc.identifier.pmid 26700418
dc.type.publication post-print
dc.citation.firstpage 23
dc.citation.lastpage 29


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