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dc.contributor.authorKolomeisky, Anatoly B.
Veksler, Alex
dc.date.accessioned 2017-05-03T16:12:49Z
dc.date.available 2017-05-03T16:12:49Z
dc.date.issued 2012
dc.identifier.citation Kolomeisky, Anatoly B. and Veksler, Alex. "How to accelerate protein search on DNA: Location and dissociation." The Journal of Chemical Physics, 136, (2012) AIP Publishing LLC: https://doi.org/10.1063/1.3697763.
dc.identifier.urihttps://hdl.handle.net/1911/94121
dc.description.abstract One of the most important features of biological systems that controls their functioning is the ability of protein molecules to find and recognize quickly specific target sites on DNA. Although these phenomena have been studied extensively, detailed mechanisms of protein-DNA interactions during the search are still not well understood. Experiments suggest that proteins typically find their targets fast by combining three-dimensional and one-dimensional motions, and most of the searching time proteins are non-specifically bound to DNA. However these observations are surprising since proteins diffuse very slowly on DNA, and it seems that the observed fast search cannot be achieved under these conditions for single proteins. Here we propose two simple mechanisms that might explain some of these controversial observations. Using first-passage time analysis, it is shown explicitly that the search can be accelerated by changing the location of the target and by effectively irreversible dissociations of proteins. Our theoretical predictions are supported by Monte Carlo computer simulations.
dc.language.iso eng
dc.publisher AIP Publishing LLC
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title How to accelerate protein search on DNA: Location and dissociation
dc.type Journal article
dc.citation.journalTitle The Journal of Chemical Physics
dc.citation.volumeNumber 136
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1063/1.3697763
dc.identifier.pmid 22462896
dc.type.publication publisher version
dc.citation.articleNumber 125101


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