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    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress

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    Tour, James M.; Berlin, Jacob; Marcano, Daniela; Leonard, Ashley; Kent, Thomas A.; More... Pautler, Robia G.; Bitner, Brittany; Inoue, Taeko Less...
    Date
    2017-02-21
    Abstract
    In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.
    Citation
    Tour, James M., Berlin, Jacob, Marcano, Daniela, Leonard, Ashley, Kent, Thomas A., Pautler, Robia G., Bitner, Brittany and Inoue, Taeko, "Use of carbon nanomaterials with antioxidant properties to treat oxidative stress." Patent US9572834B2. issued 2017-02-21. Retrieved from https://hdl.handle.net/1911/94105.
    Type
    Utility patent
    Citable link to this page
    https://hdl.handle.net/1911/94105
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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map