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dc.contributor.authorInupakutika, Madhuri A.
Sengupta, Soham
Nechushtai, Rachel
Jennings, Patricia A.
Onuchic, José N.
Azad, Rajeev K.
Padilla, Pamela
Mittler, Ron
dc.date.accessioned 2017-03-07T18:53:39Z
dc.date.available 2017-03-07T18:53:39Z
dc.date.issued 2017
dc.identifier.citation Inupakutika, Madhuri A., Sengupta, Soham, Nechushtai, Rachel, et al.. "Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates." Scientific Reports, 7, (2017) Springer Nature: http://dx.doi.org/10.1038/srep42571.
dc.identifier.urihttps://hdl.handle.net/1911/94034
dc.description.abstract NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are involved in the regulation of iron and reactive oxygen metabolism, and have been associated with the progression of diabetes, cancer, aging and neurodegenerative diseases. Despite their important biological functions, the evolution and diversification of eukaryotic NEET proteins are largely unknown. Here we used the three members of the human NEET protein family (CISD1, mitoNEET; CISD2, NAF-1 or Miner 1; and CISD3, Miner2) as our guides to conduct a phylogenetic analysis of eukaryotic NEET proteins and their evolution. Our findings identified the slime mold Dictyostelium discoideum’s CISD proteins as the closest to the ancient archetype of eukaryotic NEET proteins. We further identified CISD3 homologs in fungi that were previously reported not to contain any NEET proteins, and revealed that plants lack homolog(s) of CISD3. Furthermore, our study suggests that the mammalian NEET proteins, mitoNEET (CISD1) and NAF-1 (CISD2), emerged via gene duplication around the origin of vertebrates. Our findings provide new insights into the classification and expansion of the NEET protein family, as well as offer clues to the diverged functions of the human mitoNEET and NAF-1 proteins.
dc.language.iso eng
dc.publisher Springer Nature
dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
dc.type Journal article
dc.citation.journalTitle Scientific Reports
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1038/srep42571
dc.identifier.pmcid PMC5311916
dc.type.publication publisher version
dc.citation.articleNumber 42571


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