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    Role of Autoregulation and Relative Synthesis of Operon Partners in Alternative Sigma Factor Networks

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    Author
    Narula J.; Tiwari A.; Igoshin O.
    Date
    2016
    Abstract
    Despite the central role of alternative sigma factors in bacterial stress response and virulence their regulation remains incompletely understood. Here we investigate one of the best-studied examples of alternative sigma factors: the σnetwork that controls the general stress response of Bacillus subtilis to uncover widely relevant general design principles that describe the structure-function relationship of alternative sigma factor regulatory networks. We show that the relative stoichiometry of the synthesis rates of σ, its anti-sigma factor RsbW and the anti-anti-sigma factor RsbV plays a critical role in shaping the network behavior by forcing the σnetwork to function as an ultrasensitive negative feedback loop. We further demonstrate how this negative feedback regulation insulates alternative sigma factor activity from competition with the housekeeping sigma factor for RNA polymerase and allows multiple stress sigma factors to function simultaneously with little competitive interference.
    Citation
    Narula J., Tiwari A. and Igoshin O.. "Role of Autoregulation and Relative Synthesis of Operon Partners in Alternative Sigma Factor Networks." PLoS Computational Biology, 12, no. 12 (2016) Public Library of Science: http://dx.doi.org/10.1371/journal.pcbi.1005267.
    Published Version
    http://dx.doi.org/10.1371/journal.pcbi.1005267
    Type
    Journal article
    Publisher
    Public Library of Science
    Citable link to this page
    https://hdl.handle.net/1911/93978
    Rights
    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Link to License
    https://creativecommons.org/licenses/by/4.0/
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    • Bioengineering Publications [632]
    • Faculty Publications [4988]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map