Show simple item record

dc.contributor.authorZhang, B.
Wolynes, P.G.
dc.date.accessioned 2017-02-23T16:13:25Z
dc.date.available 2017-02-23T16:13:25Z
dc.date.issued 2016
dc.identifier.citation Zhang, B. and Wolynes, P.G.. "Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome." Physical Review Letters, 116, no. 24 (2016) American Physical Society: http://dx.doi.org/10.1103/PhysRevLett.116.248101.
dc.identifier.urihttps://hdl.handle.net/1911/93974
dc.description.abstract We derive an unbiased information theoretic energy landscape for chromosomes at metaphase using a maximum entropy approach that accurately reproduces the details of the experimentally measured pairwise contact probabilities between genomic loci. Dynamical simulations using this landscape lead to cylindrical, helically twisted structures reflecting liquid crystalline order. These structures are similar to those arising from a generic ideal homogenized chromosome energy landscape. The helical twist can be either right or left handed so chiral symmetry is broken spontaneously. The ideal chromosome landscape when augmented by interactions like those leading to topologically associating domain formation in the interphase chromosome reproduces these behaviors. The phase diagram of this landscape shows that the helical fiber order and the cylindrical shape persist at temperatures above the onset of chiral symmetry breaking, which is limited by the topologically associating domain interaction strength.
dc.language.iso eng
dc.publisher American Physical Society
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome
dc.type Journal article
dc.citation.journalTitle Physical Review Letters
dc.citation.volumeNumber 116
dc.citation.issueNumber 24
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevLett.116.248101
dc.type.publication publisher version
local.sword.agent Converis
dc.citation.articleNumber 248101


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record