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    Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome

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    Author
    Zhang, B.; Wolynes, P.G.
    Date
    2016
    Abstract
    We derive an unbiased information theoretic energy landscape for chromosomes at metaphase using a maximum entropy approach that accurately reproduces the details of the experimentally measured pairwise contact probabilities between genomic loci. Dynamical simulations using this landscape lead to cylindrical, helically twisted structures reflecting liquid crystalline order. These structures are similar to those arising from a generic ideal homogenized chromosome energy landscape. The helical twist can be either right or left handed so chiral symmetry is broken spontaneously. The ideal chromosome landscape when augmented by interactions like those leading to topologically associating domain formation in the interphase chromosome reproduces these behaviors. The phase diagram of this landscape shows that the helical fiber order and the cylindrical shape persist at temperatures above the onset of chiral symmetry breaking, which is limited by the topologically associating domain interaction strength.
    Citation
    Zhang, B. and Wolynes, P.G.. "Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome." Physical Review Letters, 116, no. 24 (2016) American Physical Society: http://dx.doi.org/10.1103/PhysRevLett.116.248101.
    Published Version
    http://dx.doi.org/10.1103/PhysRevLett.116.248101
    Type
    Journal article
    Publisher
    American Physical Society
    Citable link to this page
    https://hdl.handle.net/1911/93974
    Rights
    Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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    • Chemistry Publications [705]
    • Faculty Publications [5504]
    • Physics and Astronomy Publications [1883]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map