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dc.contributor.authorJin, Tao
Stanciulescu, Ilinca
dc.date.accessioned 2017-02-01T18:55:24Z
dc.date.available 2017-02-01T18:55:24Z
dc.date.issued 2017
dc.identifier.citation Jin, Tao and Stanciulescu, Ilinca. "Numerical investigation of the influence of pattern topology on the mechanical behavior of PEGDA hydrogels." Acta Biomaterialia, 49, (2017) Elsevier: 247-259. http://dx.doi.org/10.1016/j.actbio.2016.10.041.
dc.identifier.urihttps://hdl.handle.net/1911/93837
dc.description.abstract Poly(ethylene glycol) diacrylate (PEGDA) hydrogels can be potentially used as scaffold material for tissue engineered heart valves (TEHVs) due to their good biocompatibility and biomechanical tunability. The photolithographic patterning technique is an effective approach to pattern PEGDA hydrogels to mimic the mechanical behavior of native biological tissues that are intrinsically anisotropic. The material properties of patterned PEGDA hydrogels largely depend on the pattern topology. In this paper, we adopt a newly proposed computational framework for fibrous biomaterials to numerically investigate the influence of pattern topology, including pattern ratio, orientation and waviness, on the mechanical behavior of patterned PEGDA hydrogels. The material parameters for the base hydrogel and the pattern stripes are directly calibrated from published experimental data. Several experimental observations reported in the literature are captured in the simulation, including the nonlinear relationship between pattern ratio and material linear modulus, and the decrease of material anisotropy when pattern ratio increases. We further numerically demonstrate that a three-region (toe-heel-linear) stress–strain relationship typically exhibited by biological tissues can be obtained by tuning the pattern waviness and the relative stiffness between the base hydrogel and pattern stripes. The numerical strategy and simulation results presented here can provide helpful guidance to optimize pattern design of PEGDA hydrogels toward the targeted material mechanical properties, therefore advance the development of TEHVs.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Numerical investigation of the influence of pattern topology on the mechanical behavior of PEGDA hydrogels
dc.type Journal article
dc.citation.journalTitle Acta Biomaterialia
dc.subject.keywordPEGDA hydrogel
pattern topology
embedded fiber approach
dc.citation.volumeNumber 49
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2016.10.041
dc.identifier.pmid 27856282
dc.type.publication post-print
dc.citation.firstpage 247
dc.citation.lastpage 259


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