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dc.contributor.authorAlbritton, Jacob L.
Miller, Jordan S.
dc.date.accessioned 2017-01-30T22:36:08Z
dc.date.available 2017-01-30T22:36:08Z
dc.date.issued 2017
dc.identifier.citation Albritton, Jacob L. and Miller, Jordan S.. "3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments." Disease Models & Mechanisms, 10, (2017) The Company of Biologists: 14. http://dx.doi.org/10.1242/dmm.025049.
dc.identifier.urihttps://hdl.handle.net/1911/93824
dc.description.abstract Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact mechanism of metastatic progression. Currently available in vitro models cannot replicate the three-dimensionality and heterogeneity of the tumor microenvironment sufficiently to recapitulate many of the known characteristics of tumors in vivo. Our understanding of metastatic progression would thus be boosted by the development of in vitro models that could more completely capture the salient features of cancer biology. Bioengineering groups have been working for over two decades to create in vitro microenvironments for application in regenerative medicine and tissue engineering. Over this time, advances in 3D printing technology and biomaterials research have jointly led to the creation of 3D bioprinting, which has improved our ability to develop in vitro models with complexity approaching that of the in vivo tumor microenvironment. In this Review, we give an overview of 3D bioprinting methods developed for tissue engineering, which can be directly applied to constructing in vitro models of heterogeneous tumor microenvironments. We discuss considerations and limitations associated with 3D printing and highlight how these advances could be harnessed to better model metastasis and potentially guide the development of anti-cancer strategies.
dc.language.iso eng
dc.publisher The Company of Biologists
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0
dc.title 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
dc.type Journal article
dc.citation.journalTitle Disease Models & Mechanisms
dc.subject.keyword3D bioprinting
metastasis
in vitro model
tumor microenvironment
cancer
dc.citation.volumeNumber 10
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1242/dmm.025049
dc.identifier.pmid 28067628
dc.type.publication publisher version
dc.citation.firstpage 14
dc.citation.articleNumber 3


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