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    3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments

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    Author
    Albritton, Jacob L.; Miller, Jordan S.
    Date
    2017
    Abstract
    Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact mechanism of metastatic progression. Currently available in vitro models cannot replicate the three-dimensionality and heterogeneity of the tumor microenvironment sufficiently to recapitulate many of the known characteristics of tumors in vivo. Our understanding of metastatic progression would thus be boosted by the development of in vitro models that could more completely capture the salient features of cancer biology. Bioengineering groups have been working for over two decades to create in vitro microenvironments for application in regenerative medicine and tissue engineering. Over this time, advances in 3D printing technology and biomaterials research have jointly led to the creation of 3D bioprinting, which has improved our ability to develop in vitro models with complexity approaching that of the in vivo tumor microenvironment. In this Review, we give an overview of 3D bioprinting methods developed for tissue engineering, which can be directly applied to constructing in vitro models of heterogeneous tumor microenvironments. We discuss considerations and limitations associated with 3D printing and highlight how these advances could be harnessed to better model metastasis and potentially guide the development of anti-cancer strategies.
    Citation
    Albritton, Jacob L. and Miller, Jordan S.. "3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments." Disease Models & Mechanisms, 10, (2017) The Company of Biologists: 14. http://dx.doi.org/10.1242/dmm.025049.
    Published Version
    http://dx.doi.org/10.1242/dmm.025049
    Keyword
    3D bioprinting; metastasis; in vitro model; tumor microenvironment; cancer
    Type
    Journal article
    Publisher
    The Company of Biologists
    Citable link to this page
    https://hdl.handle.net/1911/93824
    Rights
    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
    Link to License
    http://creativecommons.org/licenses/by/3.0
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    • Bioengineering Publications [632]
    • Faculty Publications [4990]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map