Show simple item record

dc.contributor.authorTong, Yin
Li, Zhoufang
Zhang, Hua
Xia, Ligang
Zhang, Meng
Xu, Ying
Wang, Zhanhui
Deem, Michael W.
Sun, Xiaojuan
He, Jiankui
dc.date.accessioned 2017-01-30T17:29:31Z
dc.date.available 2017-01-30T17:29:31Z
dc.date.issued 2016
dc.identifier.citation Tong, Yin, Li, Zhoufang, Zhang, Hua, et al.. "T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients." Genomics Proteomics Bioinformatics, 14, no. 6 (2016) Elsevier: 338-348. http://dx.doi.org/10.1016/j.gpb.2016.10.003.
dc.identifier.urihttps://hdl.handle.net/1911/93806
dc.description.abstract Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual T1D patients and controls. We sequenced the T cell repertoire of nine T1D patients, four type 2 diabetes (T2D) patients, and six nondiabetic controls. The diversity of the T cell repertoire in T1D patients was significantly decreased in comparison with T2D patients (P = 7.0E−08 for CD4+ T cells, P = 1.4E−04 for CD8+ T cells) and nondiabetic controls (P = 2.7E−09 for CD4+ T cells, P = 7.6E−06 for CD8+ T cells). Moreover, T1D patients had significantly more highly-expanded T cell clones than T2D patients (P = 5.2E−06 for CD4+ T cells, P = 1.9E−07 for CD8+ T cells) and nondiabetic controls (P = 1.7E−07 for CD4+ T cells, P = 3.3E−03 for CD8+ T cells). Furthermore, we identified a group of highly-expanded T cell receptor clones that are shared by more than two T1D patients. Although further validation in larger cohorts is needed, our data suggest that T cell receptor diversity measurements may become a valuable tool in investigating diabetes, such as using the diversity as an index to distinguish different types of diabetes.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an open access article under the Creative Commons CC BY license.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients
dc.type Journal article
dc.citation.journalTitle Genomics Proteomics Bioinformatics
dc.subject.keyworddiversity
high-throughput sequencing
immune repertoire
T cell receptor
Type 1 diabetes
dc.citation.volumeNumber 14
dc.citation.issueNumber 6
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.gpb.2016.10.003
dc.identifier.pmcid PMC5200939
dc.identifier.pmid 28024918
dc.type.publication publisher version
dc.citation.firstpage 338
dc.citation.lastpage 348


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

This is an open access article under the Creative Commons CC BY license.
Except where otherwise noted, this item's license is described as This is an open access article under the Creative Commons CC BY license.