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dc.contributor.authorKhodakov, Dmitriy
Wang, Chunyan
Zhang, David Yu
dc.date.accessioned 2017-01-27T22:23:42Z
dc.date.available 2017-01-27T22:23:42Z
dc.date.issued 2016
dc.identifier.citation Khodakov, Dmitriy, Wang, Chunyan and Zhang, David Yu. "Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches." Advanced Drug Delivery Reviews, 105, Part A, (2016) Elsevier: 3-19. http://dx.doi.org/10.1016/j.addr.2016.04.005.
dc.identifier.urihttps://hdl.handle.net/1911/93798
dc.description.abstract Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an open access article under the CC BY-NC-ND license
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches
dc.type Journal article
dc.citation.journalTitle Advanced Drug Delivery Reviews
dc.subject.keywordmolecular diagnostics
nucleic acid tests
PCR
hybridization
next-generation sequencing
dc.citation.volumeNumber 105, Part A
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2016.04.005
dc.identifier.pmid 27089811
dc.type.publication publisher version
dc.citation.firstpage 3
dc.citation.lastpage 19


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