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    Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches

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    Author
    Khodakov, Dmitriy; Wang, Chunyan; Zhang, David Yu
    Date
    2016
    Abstract
    Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.
    Citation
    Khodakov, Dmitriy, Wang, Chunyan and Zhang, David Yu. "Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches." Advanced Drug Delivery Reviews, 105, Part A, (2016) Elsevier: 3-19. http://dx.doi.org/10.1016/j.addr.2016.04.005.
    Published Version
    http://dx.doi.org/10.1016/j.addr.2016.04.005
    Keyword
    molecular diagnostics; nucleic acid tests; PCR; hybridization; next-generation sequencing
    Type
    Journal article
    Publisher
    Elsevier
    Citable link to this page
    https://hdl.handle.net/1911/93798
    Rights
    This is an open access article under the CC BY-NC-ND license
    Link to License
    https://creativecommons.org/licenses/by-nc-nd/4.0/
    Metadata
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    • Bioengineering Publications [684]
    • Faculty Publications [5504]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map