Metal-Free Dual Modal Contrast Agents Based on Fluorographene Quantum Dots
Sudeep, Parambath M.
Maldonado, Kiersten L.
Mani, Sendurai A.
Tiwary, Chandra Sekhar
Singh, Abhishek K.
Ajayan, Pulickel M.
NEWS COVERAGE: A news release based on this journal publication is available online: http://news.rice.edu/2016/11/10/rice-expands-graphene-repertoire-with-mri-contrast-agent/
Fluorographene quantum dots prepared from fluorinated graphene oxide (FGO) show a linear dependence of the magnetization on the applied field. This is further supported by DFT calculations taking into account a few possible systems of functionalized graphene quantum dots. The inherent magnetism, high concentration of fluorine and cyto-compatibility of these quantum dots promise potential application as a dual modal agent for proton and 19F based Magnetic Resonance Imaging which is investigated here. A metal free dual modal contrast agent would bring about a great change in the efficiency and resolution of this widely used imaging tool.
Fluorinated graphene Quantum dots; Magnetic Resonance Imaging(MRI); Graphene; DFT Calculations; Contrast agent