Show simple item record

dc.contributor.authorKeahey, Pelham
Ramalingam, Preetha
Schmeler, Kathleen
Richards-Kortum, Rebecca R.
dc.date.accessioned 2017-01-09T18:24:39Z
dc.date.available 2017-01-09T18:24:39Z
dc.date.issued 2016
dc.identifier.citation Keahey, Pelham, Ramalingam, Preetha, Schmeler, Kathleen, et al.. "Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents." Proceedings of the National Academy of Sciences, 113, no. 9 (2016) National Academy of Sciences: 10769-10773. http://dx.doi.org/10.1073/pnas.1613497113.
dc.identifier.urihttps://hdl.handle.net/1911/93743
dc.descriptionNEWS COVERAGE: A news release based on this journal publication is available online: http://news.rice.edu/2016/09/15/improved-microendoscope-brings-cervical-cancer-into-focus/
dc.description.abstract Fiber optic microendoscopy has shown promise for visualization of molecular contrast agents used to study disease in vivo. However, fiber optic microendoscopes have limited optical sectioning capability, and image contrast is limited by out-of-focus light generated in highly scattering tissue. Optical sectioning techniques have been used in microendoscopes to remove out-of-focus light but reduce imaging speed or rely on bulky optical elements that prevent in vivo imaging. Here, we present differential structured illumination microendoscopy (DSIMe), a fiber optic system that can perform structured illumination in real time for optical sectioning without any opto-mechanical components attached to the distal tip of the fiber bundle. We demonstrate the use of DSIMe during in vivo fluorescence imaging in patients undergoing surgery for cervical adenocarcinoma in situ. Images acquired using DSIMe show greater contrast than standard microendoscopy, improving the ability to detect cellular atypia associated with neoplasia.
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents
dc.type Journal article
dc.citation.journalTitle Proceedings of the National Academy of Sciences
dc.subject.keywordmolecular imaging
cervical cancer
microendoscopy
fluorescence
structured illumination
dc.citation.volumeNumber 113
dc.citation.issueNumber 9
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.1613497113
dc.type.publication publisher version
dc.citation.firstpage 10769
dc.citation.lastpage 10773


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record