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dc.contributor.authorKim, C-Yoon
Sikkema, William K. A.
Hwang, In-Kyu
Oh, Hanseul
Kim, Un Jeng
Lee, Bae Hwan
Tour, James M.
dc.date.accessioned 2016-12-16T17:50:26Z
dc.date.available 2016-12-16T17:50:26Z
dc.date.issued 2016
dc.identifier.citation Kim, C-Yoon, Sikkema, William K. A., Hwang, In-Kyu, et al.. "Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats." Surgical Neurology International, 7, no. Suppl 24 (2016) Surgical Neurology International: S632-S636. http://dx.doi.org/10.4103/2152-7806.190475.
dc.identifier.urihttps://hdl.handle.net/1911/93727
dc.description.abstract Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.
dc.language.iso eng
dc.publisher Surgical Neurology International
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.title Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats
dc.type Journal article
dc.citation.journalTitle Surgical Neurology International
dc.contributor.org The NanoCarbon Center
dc.subject.keywordCephalosomatic anastomosis
electrophysiology
graphene nanoribbons
GEMINI
spinal cord fusion
dc.citation.volumeNumber 7
dc.citation.issueNumber Suppl 24
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.4103/2152-7806.190475
dc.identifier.pmcid PMC5025948
dc.type.publication publisher version
dc.citation.firstpage S632
dc.citation.lastpage S636


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