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    Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats

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    Author
    Kim, C-Yoon; Sikkema, William K. A.; Hwang, In-Kyu; Oh, Hanseul; Kim, Un Jeng; More... Lee, Bae Hwan; Tour, James M. Less...
    Date
    2016
    Abstract
    Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.
    Citation
    Kim, C-Yoon, Sikkema, William K. A., Hwang, In-Kyu, et al.. "Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats." Surgical Neurology International, 7, no. Suppl 24 (2016) Surgical Neurology International: S632-S636. http://dx.doi.org/10.4103/2152-7806.190475.
    Published Version
    http://dx.doi.org/10.4103/2152-7806.190475
    Keyword
    Cephalosomatic anastomosis; electrophysiology; graphene nanoribbons; GEMINI; spinal cord fusion
    Type
    Journal article
    Publisher
    Surgical Neurology International
    Citable link to this page
    https://hdl.handle.net/1911/93727
    Rights
    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
    Link to License
    https://creativecommons.org/licenses/by-nc-sa/3.0/us/
    Metadata
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    • Chemistry Publications [636]
    • Faculty Publications [4988]
    • Materials Science and NanoEngineering Publications [352]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map