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dc.contributor.authorPalejwala, Ali H.
Fridley, Jared S.
Mata, Javier A.
Samuel, Errol L.G.
Luerssen, Thomas G.
Perlaky, Laszlo
Kent, Thomas A.
Tour, James M.
Jea, Andrew
dc.date.accessioned 2016-12-07T18:50:38Z
dc.date.available 2016-12-07T18:50:38Z
dc.date.issued 2016
dc.identifier.citation Palejwala, Ali H., Fridley, Jared S., Mata, Javier A., et al.. "Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats." Surgical Neurology International, 7, (2016) http://dx.doi.org/10.4103/2152-7806.188905.
dc.identifier.urihttp://hdl.handle.net/1911/92739
dc.description.abstract Background: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. Methods: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess in vivo biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold. Results: The graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective tissue elements, blood vessels, neurofilaments, and Schwann cells around the graphene nanoscaffolds. Conclusions: Graphene is a nanomaterial that is biocompatible with neurons and may have significant biomedical application. It may provide a scaffold for the ingrowth of regenerating axons after spinal cord injury.
dc.language.iso eng
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.title Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats
dc.type Journal article
dc.citation.journalTitle Surgical Neurology International
dc.subject.keywordbiocompatibility
cytotoxicity
graphene
nanomedicine
neuron
spinal cord injury
dc.citation.volumeNumber 7
dc.contributor.publisher Surgical Neurology International
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.4103/2152-7806.188905
dc.identifier.pmcid PMC5009578
dc.type.publication publisher version
dc.citation.articleNumber 75


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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.