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    Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats

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    Palejwala, Ali H.; Fridley, Jared S.; Mata, Javier A.; Samuel, Errol L.G.; Luerssen, Thomas G.; More... Perlaky, Laszlo; Kent, Thomas A.; Tour, James M.; Jea, Andrew Less...
    Date
    2016
    Abstract
    Background: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. Methods: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess in vivo biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold. Results: The graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective tissue elements, blood vessels, neurofilaments, and Schwann cells around the graphene nanoscaffolds. Conclusions: Graphene is a nanomaterial that is biocompatible with neurons and may have significant biomedical application. It may provide a scaffold for the ingrowth of regenerating axons after spinal cord injury.
    Citation
    Palejwala, Ali H., Fridley, Jared S., Mata, Javier A., et al.. "Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats." Surgical Neurology International, 7, (2016) Surgical Neurology International: http://dx.doi.org/10.4103/2152-7806.188905.
    Published Version
    http://dx.doi.org/10.4103/2152-7806.188905
    Keyword
    biocompatibility; cytotoxicity; graphene; nanomedicine; neuron; More... spinal cord injury Less...
    Type
    Journal article
    Publisher
    Surgical Neurology International
    Citable link to this page
    https://hdl.handle.net/1911/92739
    Rights
    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
    Link to License
    https://creativecommons.org/licenses/by-nc-sa/3.0/us/
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    Collections
    • Chemistry Publications [636]
    • Faculty Publications [4988]
    • Materials Science and NanoEngineering Publications [352]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map