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dc.contributor.authorSubramanian, Kaushik
Gabay, Ilan
Ferhanoğlu, Onur
Shadfan, Adam
Pawlowski, Michal
Wang, Ye
Tkaczyk, Tomasz
Ben-Yakar, Adela
dc.date.accessioned 2016-12-01T17:29:09Z
dc.date.available 2016-12-01T17:29:09Z
dc.date.issued 2016
dc.identifier.citation Subramanian, Kaushik, Gabay, Ilan, Ferhanoğlu, Onur, et al.. "Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies." Biomedical Optics Express, 7, no. 11 (2016) The Optical Society: 4639-4653. http://dx.doi.org/10.1364/BOE.7.004639.
dc.identifier.urihttps://hdl.handle.net/1911/92733
dc.description.abstract We present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel for fast tissue microsurgery. Delivery of micro-Joules level energies to the tissue was made possible by a large, 31 μm, air-cored inhibited-coupling Kagome fiber. We overcome the fiber’s low NA by using lenses made of high refractive index ZnS, which produced an optimal focusing condition with 0.23 NA objective. The optical design achieved a focused laser spot size of 4.5 μm diameter covering a 75 × 75 μm2 scan area in a miniaturized setting. The probe could deliver the maximum available laser power, achieving an average fluence of 7.8 J/cm2 on the tissue surface at 62% transmission efficiency. Such fluences could produce uninterrupted, 40 μm deep cuts at translational speeds of up to 5 mm/s along the tissue. We predicted that the best combination of speed and coverage exists at 8 mm/s for our conditions. The onset of nonlinear absorption in ZnS, however, limited the probe’s energy delivery capabilities to 1.4 μJ for linear operation at 1.5 picosecond pulse-widths of our fiber laser. Alternatives like broadband CaF2 crystals should mitigate such nonlinear limiting behavior. Improved opto-mechanical design and appropriate material selection should allow substantially higher fluence delivery and propel such Kagome fiber-based scalpels towards clinical translation.
dc.language.iso eng
dc.publisher The Optical Society
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies
dc.type Journal article
dc.citation.journalTitle Biomedical Optics Express
dc.citation.volumeNumber 7
dc.citation.issueNumber 11
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.7.004639
dc.type.publication publisher version
dc.citation.firstpage 4639
dc.citation.lastpage 4653


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