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    Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies

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    Author
    Subramanian, Kaushik; Gabay, Ilan; Ferhanoğlu, Onur; Shadfan, Adam; Pawlowski, Michal; More... Wang, Ye; Tkaczyk, Tomasz; Ben-Yakar, Adela Less...
    Date
    2016
    Abstract
    We present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel for fast tissue microsurgery. Delivery of micro-Joules level energies to the tissue was made possible by a large, 31 μm, air-cored inhibited-coupling Kagome fiber. We overcome the fiber’s low NA by using lenses made of high refractive index ZnS, which produced an optimal focusing condition with 0.23 NA objective. The optical design achieved a focused laser spot size of 4.5 μm diameter covering a 75 × 75 μm2 scan area in a miniaturized setting. The probe could deliver the maximum available laser power, achieving an average fluence of 7.8 J/cm2 on the tissue surface at 62% transmission efficiency. Such fluences could produce uninterrupted, 40 μm deep cuts at translational speeds of up to 5 mm/s along the tissue. We predicted that the best combination of speed and coverage exists at 8 mm/s for our conditions. The onset of nonlinear absorption in ZnS, however, limited the probe’s energy delivery capabilities to 1.4 μJ for linear operation at 1.5 picosecond pulse-widths of our fiber laser. Alternatives like broadband CaF2 crystals should mitigate such nonlinear limiting behavior. Improved opto-mechanical design and appropriate material selection should allow substantially higher fluence delivery and propel such Kagome fiber-based scalpels towards clinical translation.
    Citation
    Subramanian, Kaushik, Gabay, Ilan, Ferhanoğlu, Onur, et al.. "Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies." Biomedical Optics Express, 7, no. 11 (2016) The Optical Society: 4639-4653. http://dx.doi.org/10.1364/BOE.7.004639.
    Published Version
    http://dx.doi.org/10.1364/BOE.7.004639
    Type
    Journal article
    Publisher
    The Optical Society
    Citable link to this page
    https://hdl.handle.net/1911/92733
    Rights
    Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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    • Bioengineering Publications [632]
    • Faculty Publications [4988]

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    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map