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dc.contributor.authorPuperi, Daniel S.
Balaoing, Liezl R.
O'Connell, Ronan W.
West, Jennifer L.
Grande-Allen, K. Jane
dc.date.accessioned 2016-10-21T17:01:00Z
dc.date.available 2016-10-21T17:01:00Z
dc.date.issued 2015
dc.identifier.citation Puperi, Daniel S., Balaoing, Liezl R., O'Connell, Ronan W., et al.. "3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model." Biomaterials, 67, (2015) 354-364. http://dx.doi.org/10.1016/j.biomaterials.2015.07.039.
dc.identifier.urihttps://hdl.handle.net/1911/91982
dc.description.abstract Physiologically relevant inᅠvitro models are needed to study disease progression and to develop and screen potential therapeutic interventions for disease. Heart valve disease, in particular, has no early intervention or non-invasive treatment because there is a lack of understanding the cellular mechanisms which lead to disease. Here, we establish a novel, customizable synthetic hydrogel platform that can be used to study cell-cell interactions and the factors which contribute to valve disease. Spatially localized cell adhesive ligands bound in the scaffold promote cell growth and organization of valve interstitial cells and valve endothelial cells in 3D co-culture. Both cell types maintained phenotypes, homeostatic functions, and produced zonally localized extracellular matrix. This model extends the capabilities of inᅠvitro research by providing a platform to perform direct contact co-culture with cells in their physiologically relevant spatial arrangement.
dc.language.iso eng
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model
dc.type Journal article
dc.citation.journalTitle Biomaterials
dc.subject.keywordbiomimetic material
co-culture
endothelialisation
heart valve
hydrogel
scaffold
dc.citation.volumeNumber 67
dc.contributor.publisher Elsevier
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2015.07.039
dc.identifier.pmcid PMC4566924
dc.identifier.pmid 26241755
dc.type.publication post-print
dc.citation.firstpage 354
dc.citation.lastpage 364


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